Metabolic Diseases

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Normal, obese and/or diabetic study subjects.
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Colonies of dysmetabolic cynomolgus and marmosets.
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Acute, short-infusion or repeated dosing designs.
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Full clinical chemistry, clinical pathology and clinical toxicology support.
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Tissue-specific safety biomarker levels by biosampling, biopsy or microdialysis.
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Organ-specific or complete histology and pathology evaluation.

Comprehensive metabolic status testing

  • Oral or IV glucose tolerance test (GTT)
  • Meal tolerance test (MTT)
  • Lipid tolerance test (LTT)
  • Normal insulin suppression test (NIST)
  • Graded glucose infusion test (GGT)
  • Insulin tolerance test (ITT)
  • Normo-insulinemic or hyper-insulinemic glucose clamps

Comprehensive dysmetabolic biomarkers assays

  • Glucose, insulin and c-peptide (NHP validated assays)
  • Lipid panels
  • Endocrine hormone panels (NHP validated assays)